Reductive cyclodimerization of chalcones: exploring the “self-adaptability” of galvanostatic electrosynthesis

Literature Information

Publication Date 2023-11-28
DOI 10.1039/D3CC04920E
Impact Factor 6.222
Authors

Mauro Garbini


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Abstract

The “self-adaptability” of galvanostatic electrolysis was shown to assist a multistage unprecedented chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. The process, all involving the reductive events, delivered densely functionalized cyclopentanes featuring five contiguous stereocenters (25 examples, yields of up to 95%, dr values up to >20 : 1). Dedicated and combined experimental as well as electrochemical investigation revealed the key role of a dynamic kinetic resolution of the aldol intermediate for the reaction mechanism.

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Back cover

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Contents list

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