Rhodium(iii)-catalyzed three-component C(sp2)–H activation for the synthesis of amines

Literature Information

Publication Date 2023-11-13
DOI 10.1039/D3CC04665F
Impact Factor 6.222
Authors

Min Lin, Yu-Fei Wu, Zheng-Qiang Liu, Cheng Liang, Qing-Hua Li, Tang-Lin Liu


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Abstract

Rhodium-catalyzed three-component C–H bond activation of aromatics with amides and aldehydes to synthesize amines was established. The addition of copper was found to be essential to ensure the high reactivity. The mechanistic studies indicated that key intermediates formed by the transmetallization between rhodium and copper could further promote the addition between 2-(pyridin-2-yl)-phenyl-metal species and imines. A series of densely substituted amines could be conveniently prepared by this one-step, three-component procedure from commercially available substrates via C–H bond activation with water as the only by-product.

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Source Journal

Chemical Communications

Chemical Communications
CiteScore: 8.6
Self-citation Rate: 4.7%
Articles per Year: 2458

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