Continuous-flow crystallisation in 3D-printed compact devices
Literature Information
Obinna Okafor, Karen Robertson, Ruth Goodridge
A flexible and cost-effective methodology to develop compact flow devices with heat exchange ability is presented here. Additive manufacturing techniques allow the rapid design and manufacture of modular jacketed flow devices, where heat exchange can be modelled and controlled to generate efficient devices for applications in continuous-flow cooling crystallisation. As a proof of concept, the crystallisation of paracetamol has been demonstrated. The manufactured devices are effective in crystallising form II paracetamol employing metacetamol as a co-crystallising agent.
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Source Journal
Reaction Chemistry & Engineering

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.










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