Batch–flow hybrid synthesis of the antipsychotic clozapine
Literature Information
N. C. Neyt, D. L. Riley
The development of batch–flow hybrid processes is becoming an attractive prospect through which chemists can make use of the best aspects of both technologies. We have reported the implementation of an on-the-fly purification by trituration which can also be utilised to perform solvent swaps. We have demonstrated this concept through the synthesis of the antipsychotic clozapine. In addition, we report a novel means of performing a reduction of an aryl nitro group under flow conditions and an overall improved process route for the total synthesis of clozapine.
Related Literature
Structure and local reactivity of PdAg/Pd(111) surface alloys
Luis A. Mancera, R. Jürgen Behm, Axel Groß
DOI: 10.1039/C2CP42914D
Structure analysis of substrate catalyst complexes in mixtures with ultrafast two-dimensional infrared spectroscopy
Andreas T. Messmer, Katharina M. Lippert, Peter R. Schreiner
DOI: 10.1039/C2CP42863F
Enhancement of the hydrogen storage capacity of Mg(AlH4)2 by excess electrons: a DFT study
S. Karthikeyan
DOI: 10.1039/C2CP43297H
Cage lifetimes of ionic liquids as studied by the magnetic field effect probe
Tomohide Okada, Tomoaki Yago, Tadashi Takamasu, Masanobu Wakasa
DOI: 10.1039/C2CP23747D
Ruthenium sulphide thin layers as catalysts for the electrooxidation of water
Peter Bogdanoff, Carolin Zachäus, Stephan Brunken, Andreas Kratzig, Klaus Ellmer, Sebastian Fiechter
DOI: 10.1039/C2CP42348K
Methanol reactions on bimetallic Ru(0001)-based surfaces under UHV conditions
Peter Jakob
DOI: 10.1039/C2CP42765F
Unraveling the binding interaction and kinetics of a prospective anti-HIV drug with a model transport protein: results and challenges
Bijan Kumar Paul, Debarati Ray, Nikhil Guchhait
DOI: 10.1039/C2CP42539D
Chemically-synthesised, atomically-precise gold clusters deposited and activated on titania
David P. Anderson, Jason F. Alvino, Alexander Gentleman, Hassan Al Qahtani, Lars Thomsen, Matthew I. J. Polson, Gregory F. Metha, Vladimir B. Golovko, Gunther G. Andersson
DOI: 10.1039/C3CP44005B
Nanopatterning by ion implantation through nanoporous alumina masks
Wei Guan, Ian M. Ross, Umananda M. Bhatta, Jay Ghatak, Nianhua Peng, Beverley J. Inkson, Günter Möbus
DOI: 10.1039/C3CP50196E
A novel three-step method for preparation of a TiB2-promoted LiBH4–MgH2 composite for reversible hydrogen storage
Xiangdong Kang, Kuikui Wang, Yujie Zhong, Bing Yang, Ping Wang
DOI: 10.1039/C2CP43532B
You might also like
What is 3-Fluoro-2-methylbenzylamine (CAS: 771573-36-5)?
3-Fluoro-2-methylbenzylamine is an organic compound with the CAS number 771573-3...
Is Tert-butyl 2-(oxetan-3-ylidene)acetate (CAS: 1207175-03-8) safe?
Tert-butyl 2-(oxetan-3-ylidene)acetate is considered safe for its intended uses ...
What precautions should be taken when handling 4-Acetyl-2-fluorobenzonitrile (CAS: 214760-18-6)?
Proper personal protective equipment (PPE) such as gloves, goggles, and a lab co...
How is 2-Ethyl-4-methyl-1,3-thiazole (CAS: 15679-12-6) typically synthesized?
2-Ethyl-4-methyl-1,3-thiazole is commonly synthesized via the reaction of thiour...
How should 5',5''-([2,2'-Bithiophene]-5,5'-diyl)bis(([1,1':3',1''-terphenyl]-4,4''-dicarboxylic acid)) (CAS: 1227780-71-3) be stored?
This compound should be stored in a cool, dry place away from direct sunlight an...
What regulatory guidelines apply to L-Lysine Acetate Salt (CAS: 52315-92-1)?
L-Lysine Acetate Salt (CAS: 52315-92-1) is subject to various regulatory guideli...
Is 6-Fluoro-3-hydroxy-2-pyrazinecarboxamide (CAS: 259793-96-9) safe?
6-Fluoro-3-hydroxy-2-pyrazinecarboxamide (CAS: 259793-96-9) is generally conside...
What are the physical and chemical properties of 1,1'-Sulfonylbis(1H-imidazole) (CAS: 7189-69-7)?
1,1'-Sulfonylbis(1H-imidazole) is a crystalline solid with a molecular weight of...
What industries use 4-methyl-7-nitro-1H-indole-3-carbonitrile (CAS: 289483-82-5)?
4-Methyl-7-nitro-1H-indole-3-carbonitrile (CAS: 289483-82-5) is primarily used i...
How should waste containing 5-Bromo-3-indolyl-beta-galactoside (CAS: 97753-82-7) be handled?
Waste containing 5-Bromo-3-indolyl-beta-galactoside (CAS: 97753-82-7) should be ...
Source Journal
Reaction Chemistry & Engineering

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.














![5-Methoxy-1H-pyrrolo[3,2-b]pyridine structure 5-Methoxy-1H-pyrrolo[3,2-b]pyridine structure](https://static.chemtradehub.com/structs/172/17288-40-3-a8d1.webp)