A ribose-functionalized NAD+ with versatile activity for ADP-ribosylation
Literature Information
Elisa N. Stephens, Xiao-Nan Zhang, Albert T. Lam, Jiawei Li, Hua Pei
An NAD+ featuring an adenosyl 4′-azido functions as a general substrate for poly-ADP-ribose polymerases. Its derived mono- and poly-ADP-ribosylated proteins can be adequately recognized by distinct ADP-ribosylation-specific readers. This molecule represents the first ribose-functionalized NAD+ with versatile activities across different ADP-ribosyltransferases and provides insight into developing new probes for ADP-ribosylation.
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