A ribose-functionalized NAD+ with versatile activity for ADP-ribosylation

Literature Information

Publication Date 2023-11-03
DOI 10.1039/D3CC04343F
Impact Factor 6.222
Authors

Elisa N. Stephens, Xiao-Nan Zhang, Albert T. Lam, Jiawei Li, Hua Pei


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Abstract

An NAD+ featuring an adenosyl 4′-azido functions as a general substrate for poly-ADP-ribose polymerases. Its derived mono- and poly-ADP-ribosylated proteins can be adequately recognized by distinct ADP-ribosylation-specific readers. This molecule represents the first ribose-functionalized NAD+ with versatile activities across different ADP-ribosyltransferases and provides insight into developing new probes for ADP-ribosylation.

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Inside front cover

Cover

DOI: 10.1039/C7CP90002C

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