Enhancement of cryopreservation with intracellularly permeable zwitterionic polymers

Literature Information

Publication Date 2023-11-02
DOI 10.1039/D3CC04092E
Impact Factor 6.222
Authors

Ryota Yamasaki, Robin Rajan, Kazuaki Matsumura


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Abstract

A novel copolymer containing zwitterionic and methylsulfinyl structures was developed, which enhanced cryoprotective efficacy by enabling intracellular cytoplasmic permeation without relying on mediated endocytosis and diffused out of the cells within approximately 30 min, making it more advantageous than polymeric nanoparticles for the transport of membrane-impermeable cryoprotectants such as trehalose.

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