Self-assembly of alkylated lysine-dendron oxytocin amphiphiles for enhanced stability and sustained pharmacological activity

Literature Information

Publication Date 2023-10-26
DOI 10.1039/D3CC03801G
Impact Factor 6.222
Authors

Fengjuan Xie, Yingying Lin, Åsa Andersson, Liang Zhao, JingJing Wan


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Abstract

Herein, we designed alkylated lysine-dendron oxytocin amphiphiles (ALOAs) 1G-OTK and 2G-OTK, which were self-assembled into spherical nanoparticles and nanostrips, respectively, and showed superior stability compared to native oxytocin. We found similar trends in the functional activity of ALOAs and native OT for human oxytocin receptor. This work may inspire the development of peptide drugs for clinical applications.

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