I2-Catalyzed oxidative synthesis of N,4-disubstituted quinazolines and quinazoline oxides‡

Literature Information

Publication Date 2019-03-07
DOI 10.1039/C9OB00349E
Impact Factor 3.876
Authors

Nagesh Jatangi, Radha Krishna Palakodety


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Abstract

An easy and efficient approach to the synthesis of N,4-disubstituted quinazoline-2-amine and oxides is described. This transformation proceeds smoothly in the presence of molecular iodine. The metal-free protocol presented here is insensitive to air moisture and operationally simple. This versatile and synthetic methodology is broadly applicable to a variety of N,4-disubstituted quinazoline-2-amines and oxides, which are synthesized in good to excellent yields starting from readily available inexpensive precursors.

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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry
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