4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)morpholine
CAS Number:
485799-04-0
Molecular Formula:
C15H23BN2O3
Process analytical technology (PAT): applications to flow processes for active pharmaceutical ingredient (API) development
Literature Information
Publication Date
2022-03-31
DOI
10.1039/D2RE00004K
Impact Factor
4.239
Authors
Courtney N. Talicska, Eamon C. O'Connell, Howard W. Ward, Angel R. Diaz, Mark A. Hardink, Douglas Connolly, Kevin P. Girard, Tomislav Ljubicic
View Original
Abstract
As flow processes are being increasingly utilized for development of active pharmaceutical ingredients (APIs), the importance of process analytical technology (PAT) in the pharmaceutical industry is growing. Here, we describe a variety of PAT tools (FTIR, on-line UPLC-MS, flow NMR) used in support of flow chemistry platforms at Pfizer as part of the Flexible API Supply Technology (FAST) initiative. A blend of qualitative and quantitative PAT approaches are described, with each method tailored to the specific aims of each individual platform. PAT is demonstrated to be beneficial for real-time process understanding and for rapid optimization of chemical reactions in the flow-chemistry space, reducing the need for off-line analytics and helping to accelerate development timelines.
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Source Journal
Reaction Chemistry & Engineering
CiteScore:
0
Self-citation Rate:
8.8%
Articles per Year:
284
Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.
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