Ultra-thin silica shell-guarded nanoflares for high-fidelity live cell miRNA-21 imaging by fully avoiding the interference of biothiols
Literature Information
Publication Date
2022-11-07
DOI
10.1039/D2AN01441F
Impact Factor
4.616
Authors
Yuze Luo, Zefeng Wang, Junqin Li, Wenhua Yi, Ke Yang, Chunlei Ou, Le Deng, Dinggeng He
View Original
Abstract
We successfully constructed a new class of nanoflares based on ultra-thin silica-coated gold nanoparticles (Au@SiO2) with the covalent binding of nucleic acids, which demonstrated more resistance to biothiols than that exhibited in the traditional Au–S binding strategy, for imaging the target miRNA-21 with high fidelity in living cells.
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