Reconfiguring workup steps in multi-cycle extractive bioconversion for sustainable fatty alcohol production: a process engineering approach
Literature Information
Publication Date
2021-10-15
DOI
10.1039/D1RE00394A
Impact Factor
4.239
Authors
Supacha Buttranon, Juthamas Jaroensuk, Patchara Chaichol, Pimchai Chaiyen
View Original
Abstract
In situ extraction offers an effective way to recover products during microbial production of fatty alcohols, which can be operated in multi-cycle mode. Workup steps may be required to increase the driving force for the extraction or to minimize by-product accumulation. Different workup steps, including intermittent glucose addition, dodecane change, and buffer change, were investigated in this study. We demonstrated that reconfiguration of these workup steps (e.g. rare intermittent workup steps) between bioconversion cycles led to significantly improved productivity and sustainability. The optimized reconfiguration enhanced the yield (0.071 g fatty alcohol per g glucose) while reducing the E-factor to 34.98, which was 120-fold lower than that of the control condition without in situ extraction. The results from this work shed light on the sustainable process development of the fatty alcohol production.
Recommended Journals
Journal of Physics and Chemistry of Solids
Organic Preparations and Procedures International
Helvetica Chimica Acta
Journal of Catalysis
Science Progress
Journal of Heterocyclic Chemistry
Proceedings of the National Academy of Sciences of the United States of America
Israel Journal of Chemistry
Journal of Medicinal Chemistry
Science
Related Literature
Cross coupling reactions of organozinc iodides with solid-supported electrophiles: synthesis of 4-substituted benzoic and 3-substituted (E)- and (Z)-propenoic acids and amides
Leslie J. Oates, Richard F. W. Jackson, Michael H. Block
2002-11-29
Paper
DOI: 10.1039/B208632H
Manganese(iii) acetate-mediated alkylation of β-keto esters and β-keto amides: an enantio- and diastereo-selective approach to substituted pyrrolidinones
Gregory Bar, Andrew F. Parsons, C. Barry Thomas
2002-12-13
Paper
DOI: 10.1039/B209123B
A rapid cell-permeating turn-on probe for sensitive and selective detection of sulfite in living cells
Jing Xu, Da-Jun Zheng, Mi-Mi Su, Yan-Chi Chen, Qing-Cai Jiao
2018-08-30
Paper
DOI: 10.1039/C8OB01908H
Aminative Umpolung cyclization for synthesis of chiral exocyclic vicinal diamines
Feng Liu, Guoqing Zhao, Weiqi Cai, Dongfang Xu, Baoguo Zhao
2018-09-26
Paper
DOI: 10.1039/C8OB02000K
Molecular tweezers with a rotationally restricted linker and freely rotating porphyrin moieties
Rhys B. Murphy, Duc-Truc Pham, Jonathan M. White, Stephen F. Lincoln, Martin R. Johnston
2018-08-14
Paper
DOI: 10.1039/C8OB00944A
Reactions of 5-mercaptoazoles and pyridine-2-thiones with acetylenic esters. Selectivity of the formation of novel fused thiazin-4-ones and thiazolidin-4-ones
Vasiliy A. Bakulev, Vera S. Berseneva, Natalia P. Belskaia, Yury Yu. Morzherin, Andreiy Zaitsev, Wim Dehaen, Ingrid Luyten, Suzanne Toppet
2002-12-05
Paper
DOI: 10.1039/B207854F
Catalytic asymmetric Henry reactions of silyl nitronates with aldehydes
Tine Risgaard, Kurt V. Gothelf, Karl Anker Jørgensen
2002-12-03
Paper
DOI: 10.1039/B208859M
Synthesis and application of a new chiral monodentate spiro phosphoramidite ligand based on hexamethyl-1,1′-spirobiindane backbone in asymmetric hydroamination/arylation of alkenes
Huanyu Shan, Rihuang Pan, Xufeng Lin
2018-08-16
Communication
DOI: 10.1039/C8OB01785A
Copper-catalyzed oxidative multicomponent reaction: synthesis of imidazo fused heterocycles with molecular oxygen
Xianwei Li, Tianzhang Wang, Yu-Jing Lu, Shaomin Ji, Yanping Huo, Bifu Liu
2018-08-02
Paper
DOI: 10.1039/C8OB01532E
Azlactone-based heterobifunctional linkers with orthogonal clickable groups: efficient tools for bioconjugation with complete atom economy
Hien The Ho, Alexandre Bénard, Gwenaël Forcher, Maël Le Bohec, Véronique Montembault, Sagrario Pascual, Laurent Fontaine
2018-09-19
Communication
DOI: 10.1039/C8OB01807C
You might also like
Compound Q&A
What is the market or research trend for N-(4-Methoxybenzyl)-2-pyridinamine (CAS: 52818-63-0)?
N-(4-Methoxybenzyl)-2-pyridinamine (CAS: 52818-63-0) is increasingly being used ...
52818-63-0N-(4-Methoxybenzyl)-...
Compound Q&A
What precautions should be taken when handling Ethyl 4-(2-chlorophenyl)-1,3-thiazole-2-carboxylate (CAS: 1050507-06-6)?
When handling Ethyl 4-(2-chlorophenyl)-1,3-thiazole-2-carboxylate, appropriate p...
1050507-06-6Ethyl 4-(2-chlorophe...
Compound Q&A
What regulatory guidelines apply to diethyldiselane (CAS: 628-39-7)?
Diethyldiselane (CAS: 628-39-7) is classified under the Globally Harmonized Syst...
628-39-7Diethyldiselane
Compound Q&A
What is the market or research trend for oxocopper (CAS: 12053-18-8)?
The market for oxocopper (CAS: 12053-18-8) is primarily driven by its use in cat...
12053-18-8oxocopper; oxo-(oxoc...
Compound Q&A
What is the market or research trend for 5-{[(2-Methyl-2-propanyl)oxy]carbonyl}-5-azaspiro[2.4]heptane-7-carboxylic acid?
The market for 5-{[(2-Methyl-2-propanyl)oxy]carbonyl}-5-azaspiro[2.4]heptane-7-c...
1268519-54-55-{[(2-Methyl-2-prop...
Compound Q&A
What is 2-(1-Pyrrolidinyl)-4-pyridinamine (CAS: 35981-63-6)?
2-(1-Pyrrolidinyl)-4-pyridinamine is a chemical compound with the CAS number 359...
35981-63-62-(1-Pyrrolidinyl)-4...
Compound Q&A
What are the physical and chemical properties of 2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane (CAS: 91556-75-1)?
2-(3-Pyridinyl)-1-azabicyclo[2.2.2]octane (CAS: 91556-75-1) is a crystalline sol...
91556-75-12-(3-Pyridinyl)-1-az...
Compound Q&A
How is (S)-Alpha-allyl-proline hydrochloride (CAS: 129704-91-2) typically synthesized?
(S)-Alpha-allyl-proline hydrochloride is usually synthesized via a Wittig reacti...
129704-91-2(S)-Alpha-allyl-prol...
Compound Q&A
What is 3-Methyl-1,2-oxazole-5-carboxylic acid (CAS: 4857-42-5)?
3-Methyl-1,2-oxazole-5-carboxylic acid (CAS: 4857-42-5) is an organic compound w...
4857-42-53-Methyl-1,2-oxazole...
Compound Q&A
How is Lys-SMCC-DM1 (CAS: 1281816-04-3) typically synthesized?
Lys-SMCC-DM1 is synthesized via a multi-step process involving the coupling of S...
1281816-04-3Lys-SMCC-DM1
Source Journal
Reaction Chemistry & Engineering
CiteScore:
0
Self-citation Rate:
8.8%
Articles per Year:
284
Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.
Recommended Compounds
![1-oxaspiro[4.4]nonan-6-one structure](https://static.chemtradehub.com/structs/134/134179-01-4-e051.webp "1-oxaspiro[4.4]nonan-6-one structure")
N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine hydrochloride (1:1)
CAS Number:
1188266-11-6
Molecular Formula:
C18H20ClNOS
![1-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-benzo[d]imidazol-2(3H)-one structure](https://static.chemtradehub.com/structs/603/60373-71-9-7dfb.webp "1-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-benzo[d]imidazol-2(3H)-one structure")
1-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS Number:
60373-71-9
Molecular Formula:
C19H19N3O
1-Isobutyl-7-methoxy-2,3,4,9-tetrahydro-1H-beta-carboline
CAS Number:
175975-76-5
Molecular Formula:
C16H22N2O
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.