Introducing deep eutectic solvents in enolate chemistry: synthesis of 1-arylpropan-2-ones under aerobic conditions

Literature Information

Publication Date 2021-08-13
DOI 10.1039/D1RE00297J
Impact Factor 4.239
Authors

Paola Vitale, Luciana Cicco, Filippo Maria Perna, Vito Capriati


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Abstract

Alkoxide-mediated enolization of 1-arylpropan-2-ones and their fluorinated derivatives, followed by α-functionalization with nucleophilic addition and substitution reactions, has been accomplished in the environmentally friendly eutectic mixture choline chloride/urea, under aerobic conditions. The usefulness of this new protocol has also been exemplified through the synthesis of a small selection of building-block like molecules through Pd-catalyzed α-arylation reactions.

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Reaction Chemistry & Engineering

Reaction Chemistry & Engineering
CiteScore: 0
Self-citation Rate: 8.8%
Articles per Year: 284

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.

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