An MeSeSO3Na reagent for oxidative aminoselenomethylation of maleimides
Literature Information
Yujing Yao, Wenliang Zhang
Herein, we describe the design and synthesis of an MeSeSO3Na reagent, which proved to be a versatile selenomethylation reagent for copper-catalyzed aminoselenomethylation of maleimides. This simple and efficient catalytic system is applicable for late-stage vinylselenomethylation of secondary amine-containing pharmaceuticals and two-fold aminoselenomethylation reactions. Most importantly, the current strategy provides a direct and convenient method for the incorporation of the SeCD3 group.
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Organic Chemistry Frontiers

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry










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