Nonmetal-catalyzed hydroamination of ynamides with amines
Literature Information
Publication Date
2021-09-09
DOI
10.1039/D1QO01052B
Impact Factor
5.281
Authors
Yanru Wang, Zhen Zhao, Songkui Lv, Lixia Ding, Xiao-Na Wang, Junbiao Chang
View Original
Abstract
The first metal-free catalytic regioselective hydroamination of ynamides with primary and secondary amines has been achieved by using TfOH as the catalyst under mild reaction conditions. This appealing strategy provides the corresponding N-arylimines and ethene-1,1-diamines in good to excellent yields with wide functional group tolerance. Furthermore, their applications in 2-aminoindole syntheses have been presented.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
cis-3-Amino-1-(trifluoromethyl)cyclobutanol hydrochloride (1:1)
CAS Number:
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Molecular Formula:
C5H9ClF3NO
6-Bromo-3,4-dihydro-2H-1,4-benzoxazine hydrochloride (1:1)
CAS Number:
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Molecular Formula:
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