Bioinspired cyclization of in situ generated γ-indolyl β,γ-unsaturated α-keto esters via an oxidative enamine process: facile approaches to pyrano[2,3-b]indoles

Literature Information

Publication Date 2021-09-17
DOI 10.1039/D1QO00996F
Impact Factor 5.281
Authors

Man Wang, Qirui Xiang, Wen Si, Ran Song, Daoshan Yang, Ming Li, Jian Lv


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Abstract

A bioinspired cyclization of in situ generated γ-indolyl β,γ-unsaturated α-ketoesters with an oxoammonium salt via an oxidative enamine process has been developed. Under mild conditions, the reactions afforded pyrano[2,3-b]indoles, which are found in a wide range of bioactive compounds, in good yields (up to 86% yield).

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Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

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