2-(3'-Chlorobiphenyl-3-yl)-4,6-diphenyl-1,3,5-triazine
CAS Number:
1443049-83-9
Molecular Formula:
C27H18ClN3
Stereoselective synthetic strategies of stereogenic carbon centers featuring a difluoromethyl group
Literature Information
Publication Date
2021-03-15
DOI
10.1039/D1QO00032B
Impact Factor
5.281
Authors
Fengyun Gao, Boyu Li, Yalan Wang, Qushuo Chen, Yongzhen Li, Kairong Wang, Wenjin Yan
View Original
Abstract
Difluoromethyl groups possess specific steric and electronic properties due to their slightly acidic C–H bonds and the natural characteristics of fluorine atoms, which allow them to act as chemically inert hydrogen-bond donors and then as surrogates in a wide assortment of important molecular recognition processes. As a result, the construction of chiral carbon centres bearing difluoromethyl groups is not only valuable for the synthesis of various fluorine-containing compounds, but also useful for the modulation of the properties of organic compounds in drug design. The scope of this review is to summarize routine asymmetric synthetic methods which enable the effective and selective introduction of difluoromethyl groups into the desired compounds.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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