High-efficiency and minimum-waste continuous kinetic resolution of racemic alcohols by using lipase in supercritical carbon dioxide
Literature Information
Tomoko Matsuda, Kazunori Watanabe, Tadao Harada, Kaoru Nakamura, Yoshitaka Arita, Yukihiro Misumi, Shinichiro Ichikawa, Takao Ikariya
A novel continuous-flow scCO2 process for kinetic resolution of racemic alcohols can be performed with an immobilized lipase to lead to a quantitative mixture of the corresponding optically active acetates with up to 99% ee and unreacted alcohols with up to 99% ee, in which the productivity of the optically active compounds was improved by over 400 times compared to the corresponding batch reaction using scCO2.
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Chemical Communications

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