High-efficiency and minimum-waste continuous kinetic resolution of racemic alcohols by using lipase in supercritical carbon dioxide

Literature Information

Publication Date 2004-08-26
DOI 10.1039/B406882C
Impact Factor 6.222
Authors

Tomoko Matsuda, Kazunori Watanabe, Tadao Harada, Kaoru Nakamura, Yoshitaka Arita, Yukihiro Misumi, Shinichiro Ichikawa, Takao Ikariya


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Abstract

A novel continuous-flow scCO2 process for kinetic resolution of racemic alcohols can be performed with an immobilized lipase to lead to a quantitative mixture of the corresponding optically active acetates with up to 99% ee and unreacted alcohols with up to 99% ee, in which the productivity of the optically active compounds was improved by over 400 times compared to the corresponding batch reaction using scCO2.

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