![6-(Benzyloxy)-8-(2-bromoacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one structure](https://static.chemtradehub.com/structs/926/926319-53-1-2287.webp "6-(Benzyloxy)-8-(2-bromoacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one structure")
6-(Benzyloxy)-8-(2-bromoacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
CAS Number:
926319-53-1
Molecular Formula:
C17H14BrNO4
Synthesis and characterization of a pH-responsive mesalazine-polynorbornene supramolecular assembly
Literature Information
Publication Date
2021-03-05
DOI
10.1039/D1PY00194A
Impact Factor
5.582
Authors
Vajk Farkas, Gábor Turczel, János Deme, László Trif, Anvar Mirzaei, Dang Vu Hai, Sándor Kéki, Péter Huszthy, Róbert Tuba
View Original
Abstract
A pH-responsive mesalazine–crown ether and perfluoro tert-butyl functionalized polynorbornene supramolecular assembly (smc-1-4-cp-1-5) has been prepared. A promoted mesalazine (1) anti-inflammatory drug sustained release has been observed at elevated pH (7–9) enabling targeted topical and sustained drug dosing in the inflamed lower gastrointestinal (GI) tract. Thermoanalytical and solid-state NMR investigations of the supramolecular assembly revealed an amorphous, solid solvent structure showing that 1 is evenly distributed in the supramolecular polymer framework. In situ1H NMR investigation revealed a downshift of the respective hydrogens upon mesalazine–supramolecular polymer assembly formation. The equilibrium constant of the complex of crown ether-functionalized norbornene monomer (5) and 1 (log K = 3.4 ± 0.5, in a DMSO-d6–CD2Cl2 1 : 1 mixture) was calculated.
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Source Journal
Polymer Chemistry
CiteScore:
8.6
Self-citation Rate:
7.3%
Articles per Year:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
Recommended Compounds
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Ethyl 4-[8-chloro(5,5,6,6,7-~2~H_5_)-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidinecarboxylate
CAS Number:
1020719-57-6
Molecular Formula:
C22H18D5ClN2O2
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