Virtual screening and in vitro validation identifies the first reported inhibitors of Salmonella enterica HPPK
Literature Information
Publication Date
2021-08-23
DOI
10.1039/D1MD00237F
Impact Factor
0
Authors
Ronel Müller, Tiaan M. Gerwel, Magambo Phillip Kimuda, Özlem Tastan Bishop, Clinton G. L. Veale, Heinrich C. Hoppe
View Original
Abstract
HPPK, which directly precedes DHPS in the folate biosynthetic pathway, is a promising but chronically under-exploited anti-microbial target. Here we report the identification of new S. enterica HPPK inhibitors, offering potential for new resistance circumventing S. enterica therapies as well as avenues for diversifying the current HPPK inhibitor space.
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