6-Butyl-2-(2,4-difluorophenyl)-1,3,6,2-dioxazaborocane
CAS Number:
1190988-98-7
Molecular Formula:
C14H20BF2NO2
Recent advances in the development of covalent inhibitors
Literature Information
Publication Date
2021-05-04
DOI
10.1039/D1MD00068C
Impact Factor
0
Authors
Hyunsoo Kim, Yoon Soo Hwang, Mingi Kim
View Original
Abstract
The use of covalent inhibitors in the field of drug discovery has attracted considerable attention in the 2000s. As a result, more than 50 covalent drugs are currently on the market, and numerous covalent drug candidates are now under development. Therefore, interest in covalent drugs is expected to continue in the future. The purpose of this focused review is to provide an understanding of the development of covalent inhibitors by describing their inherent characteristics, possibilities, and limitations based on their mechanistic differences from noncovalent inhibitors. We also introduce the latest covalent warheads that can be applied to the development of potential covalent inhibitors.
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Source Journal
Recommended Compounds
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2-Methyl-2-propanyl [2-(2-oxa-6-azaspiro[3.3]hept-6-yl)ethyl]carbamate
CAS Number:
1415562-38-7
Molecular Formula:
C12H22N2O3
![1-(2-Chlorophenyl)-6-[(2S)-3,3,3-trifluoro-2-methylpropyl]-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one structure](https://static.chemtradehub.com/structs/794/794568-91-5-0c34.webp "1-(2-Chlorophenyl)-6-[(2S)-3,3,3-trifluoro-2-methylpropyl]-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one structure")
1-(2-Chlorophenyl)-6-[(2S)-3,3,3-trifluoro-2-methylpropyl]-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
CAS Number:
794568-91-5
Molecular Formula:
C15H12ClF3N4O
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