Nuclear localization signal-tagged systems: relevant nuclear import principles in the context of current therapeutic design

Literature Information

Publication Date 2023-11-30
DOI 10.1039/D1CS00269D
Impact Factor 54.564
Authors

Ritabrita Goswami, Aarohi Gupta, Olga Bednova, Gaël Coulombe, Dipika Patel, Vincent M. Rotello


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Abstract

Nuclear targeting of therapeutics provides a strategy for enhancing efficacy of molecules active in the nucleus and minimizing off-target effects. ‘Active’ nuclear-directed transport and efficient translocations across nuclear pore complexes provide the most effective means of maximizing nuclear localization. Nuclear-targeting systems based on nuclear localization signal (NLS) motifs have progressed significantly since the beginning of the current millennium. Here, we offer a roadmap for understanding the basic mechanisms of nuclear import in the context of actionable therapeutic design for developing NLS-therapeutics with improved treatment efficacy.

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Front/Back Matter

DOI: 10.1039/C6QO90006B

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Chemical Society Reviews

Chemical Society Reviews
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Chem Soc Rev publishes review articles covering important topics at the forefront of the chemical sciences. Reviews should be of the very highest quality and international impact. We particularly encourage international and multidisciplinary collaborations among our authors. Our scope covers the breadth of the chemical sciences, including interdisciplinary topics where the article has a basis in chemistry. Topics include: Analytical chemistry Biomaterials chemistry Bioorganic/medicinal chemistry Catalysis Chemical Biology Coordination Chemistry Crystal Engineering Energy Sustainable chemistry Green chemistry Inorganic chemistry Inorganic materials Main group chemistry Nanoscience Organic chemistry Organic materials Organometallics Physical chemistry Supramolecular chemistry Synthetic methodology Theoretical and computational chemistry

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