Evolution of flow-oriented design strategies in the continuous preparation of pharmaceuticals
Literature Information
Zsolt Fülöp, Péter Szemesi, Péter Bana, János Éles, István Greiner
The dynamic progress in the multi-step continuous-flow synthesis of active pharmaceutical ingredients is part of the current industrial revolution. The recently implemented examples are the forerunners of safer and more sustainable pharmaceutical manufacturing. These systems utilize interconnected flow apparatuses, integrated with in-line work-up, purification and analysis. Challenging targets call for customized, flow-oriented designs to establish novel, telescoped continuous-flow sequences. In this review we focus on these efforts towards the development of uninterrupted continuous-flow systems.
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Source Journal
Reaction Chemistry & Engineering

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.














