Carbene-catalyzed selective addition of isothioureas to enals for access to sulphur-containing 5,6-dihyropyrimidin-4-ones
Literature Information
Publication Date
2020-12-11
DOI
10.1039/D0QO01380C
Impact Factor
5.281
Authors
Rakesh Maiti, Jia-Lei Yan, Bivas Mondal, Xing Yang, Huifang Chai, Lin Hao, Zhichao Jin
View Original
Abstract
A carbene-catalyzed addition reaction between isothioureas and enals under oxidative conditions is reported. The key steps of our reactions involve the formation of two carbon–nitrogen bonds in a highly regio-selective manner. A variety of sulphur-containing 5,6-dihydropyrimidin-4-ones are obtained with high optical purity.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
N,N-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyrimidinamine
CAS Number:
1032759-30-0
Molecular Formula:
C12H20BN3O2
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