Synthesis of polysubstituted quinolines through promoter-regulated selective annulation and C–C bond cleavage from 2-styrylanilines and β-keto esters
Literature Information
Publication Date
2020-07-01
DOI
10.1039/D0QO00709A
Impact Factor
5.281
Authors
Hui Xu, Fei Yu, Ronglu Huang, Mingyue Weng, Hong Chen, Ze Zhang
View Original
Abstract
A powerful construction of 2-alkylquinolines and quinoline-2-carboxylates has been successfully accomplished employing I2 and Mn(OAc)3, respectively, to promote the annulation of 2-styrylanilines and β-keto esters accompanied by selective C–C bond cleavage. Following this promoter-regulated strategy, various 2-alkylquinolines and quinoline-2-carboxylates were chemoselectively synthesized from easily available 2-styrylanilines and β-keto esters. The reaction mechanism is also tentatively investigated.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
1-(5-Bromo-2-fluorophenyl)-2,2,2-trifluoroethanol
CAS Number:
1039827-16-1
Molecular Formula:
C8H5BrF4O
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