A one-pot three-component strategy for highly diastereoselective synthesis of spirocycloalkane fused pyrazolo[3,4-b]pyridine derivatives using recyclable solid acid as a catalyst
Literature Information
Publication Date
2020-07-22
DOI
10.1039/D0QO00591F
Impact Factor
5.281
Authors
Furen Zhang, Chunmei Li, Chenze Qi
View Original
Abstract
An efficient and eco-friendly approach for highly diastereoselective synthesis of spirocycloalkane fused pyrazolo[3,4-b]pyridine derivatives has been developed. The one-pot three-component reaction enables multiple bond-forming events including C–C and C–N bonds under mild conditions using easily available starting materials, leading to diastereoselective generation of N-containing spirocycles. The advantages of inexpensive and easily available starting materials, green and mild reaction conditions, recyclable and easily separable heterogeneous catalysts, broad substrate scope and simple one-pot operation make this strategy highly attractive.
Related Literature
Structure and photoluminescence properties of a novel apatite green phosphor Ba5(PO4)2SiO4:Eu2+ excited by NUV light
Xin Ding, Yuhua Wang
2016-12-14
Paper
DOI: 10.1039/C6CP08300E
On the ionophoric selectivity of nonactin and related macrotetrolide derivatives
Bruno Martínez-Haya, Juan Ramón Avilés-Moreno, Said Hamad, José Elguero
2016-12-06
Paper
DOI: 10.1039/C6CP05324F
In situ X-ray absorption near edge structure studies and charge transfer kinetics of Na6[V10O28] electrodes
Chun-Jern Pan, Ali Haider, Rami Al-Oweini, Ming-Hsien Lin, Ulrich Kortz
2017-01-16
Paper
DOI: 10.1039/C6CP05768C
OH production from the photolysis of isoprene-derived peroxy radicals: cross-sections, quantum yields and atmospheric implications
Robert F. Hansen, Tom R. Lewis, Lee Graham
2016-12-12
Paper
DOI: 10.1039/C6CP06718B
New insight into the roles of oxygen vacancies in hematite for solar water splitting
Xin Zhao, Jianyong Feng, Shi Chen, Yizhong Huang, Tze Chien Sum, Zhong Chen
2016-10-27
Paper
DOI: 10.1039/C6CP06410H
Charge ordering and scattering pre-peaks in ionic liquids and alcohols
2016-12-06
Paper
DOI: 10.1039/C6CP07834F
Liberation of three dihydrogens from two ethene molecules as mediated by the tantalum nitride anion cluster Ta3N2− at room temperature
Ji-Chuang Hu, Lin-Lin Xu, Hai-Fang Li, David Yubero Valdivielso, André Fielicke, Sheng-Gui He, Jia-Bi Ma
2016-11-29
Paper
DOI: 10.1039/C6CP06896K
An unexpected bridge between chemical bonding indicators and electrical conductivity through the localization tensor
Ángel Martín Pendás, José Manuel Guevara-Vela, Daniel Menéndez Crespo, Aurora Costales, Evelio Francisco
2016-12-12
Paper
DOI: 10.1039/C6CP07617C
The electronic character of PTCDA thin films in comparison to other perylene-based organic semi-conductors: ab initio-, TD-DFT and semi-empirical computations of the opto-electronic properties of large aggregates
Daniel Bellinger, Christoph Brüning, Volker Engel, Bernd Engels
2016-12-21
Paper
DOI: 10.1039/C6CP07673D
A first-principles study of the preventive effects of Al and Mg doping on the degradation in LiNi0.8Co0.1Mn0.1O2 cathode materials
Kyoungmin Min, Seung-Woo Seo, You Young Song, Hyo Sug Lee, Eunseog Cho
2016-11-15
Paper
DOI: 10.1039/C6CP06270A
You might also like
Compound Q&A
Is 2-(2-chloroacetamido)-3-phenylpropanoic acid (CAS: 7765-11-9) safe?
2-(2-Chloroacetamido)-3-phenylpropanoic acid (CAS: 7765-11-9) is generally consi...
7765-11-92-(2-chloroacetamido...
Compound Q&A
Is 2-(Benzyloxy)-5-bromobenzoic acid (CAS: 62176-31-2) safe?
2-(Benzyloxy)-5-bromobenzoic acid can be handled safely if appropriate precautio...
62176-31-22-(Benzyloxy)-5-brom...
Compound Q&A
What is (4-Methyl-1,2,5-oxadiazol-3-yl)methanamine hydrochloride (CAS: 1159825-48-5)?
(4-Methyl-1,2,5-oxadiazol-3-yl)methanamine hydrochloride is a chemical compound ...
1159825-48-5(4-Methyl-1,2,5-oxad...
Compound Q&A
What is 2-(5-Hexylthiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS: 917985-54-7)?
2-(5-Hexylthiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS: 917985-54...
917985-54-72-(5-Hexylthiophen-2...
Compound Q&A
Are there alternatives to 4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)benzenamine (CAS: 102771-26-6) in synthesis?
While 4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)benzenamine (CAS:...
102771-26-64-(8-Methyl-9H-1,3-d...
Compound Q&A
What is the market or research trend for tert-butyl 3-hydroxy-4,5,7,8-tetrahydro-2H-pyrazolo[3,4-d]azepine-6-carboxylate (CAS: 851376-80-2)?
The market for tert-butyl 3-hydroxy-4,5,7,8-tetrahydro-2H-pyrazolo[3,4-d]azepine...
851376-80-2tert-butyl 3-hydroxy...
Compound Q&A
How should waste containing 3,5-Diamino-1H-pyrazole-4-carbonitrile (CAS: 6844-58-2) be handled?
Waste containing 3,5-Diamino-1H-pyrazole-4-carbonitrile (CAS: 6844-58-2) should ...
6844-58-23,5-Diamino-1H-pyraz...
Compound Q&A
How is (6-Fluoro-3-pyridinyl)boronic acid (CAS: 351019-18-6) typically synthesized?
(6-Fluoro-3-pyridinyl)boronic acid can be synthesized through the reaction of 6-...
351019-18-6(6-Fluoro-3-pyridiny...
Compound Q&A
What industries use Dibenzyl carbonimidoylbiscarbamate (CAS: 10065-79-9)?
Dibenzyl carbonimidoylbiscarbamate (CAS: 10065-79-9) finds applications in vario...
10065-79-9Dibenzyl carbonimido...
Compound Q&A
What is the market or research trend for (beta,beta,2,3,4,5,6-~2~H_7_)Phenylalanine (CAS: 74228-83-4)?
The market for (beta,beta,2,3,4,5,6-~2~H_7_)Phenylalanine (CAS: 74228-83-4) is g...
74228-83-4(beta,beta,2,3,4,5,6...
Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
![19-[Chloro(dideuterio)methyl]-19-deuterio-20,20-dideuteriooxyoctatriacontane-18,21-dione structure](https://static.chemtradehub.com/structs/124/1246818-85-8-6244.webp "19-[Chloro(dideuterio)methyl]-19-deuterio-20,20-dideuteriooxyoctatriacontane-18,21-dione structure")
19-[Chloro(dideuterio)methyl]-19-deuterio-20,20-dideuteriooxyoctatriacontane-18,21-dione
CAS Number:
1246818-85-8
Molecular Formula:
C39H75ClO4
![(1R)-N-((1R)-1-Phenylethyl)-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine structure](https://static.chemtradehub.com/structs/672/672314-45-3-47ef.webp "(1R)-N-((1R)-1-Phenylethyl)-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine structure")
(1R)-N-((1R)-1-Phenylethyl)-1-[4-(tert-butyldimethylsilyloxymethyl)cyclohexyl]ethan-1-amine
CAS Number:
672314-45-3
Molecular Formula:
C23H41NOSi
![{3-[Bis(4-hydroxyphenyl)methyl]-1-[2-(dimethylamino)ethyl]-1H-indol-2-yl}[4-(2-chlorophenyl)-1-piperazinyl]methanone structure](https://static.chemtradehub.com/structs/170/170365-25-0-e4d7.webp "{3-[Bis(4-hydroxyphenyl)methyl]-1-[2-(dimethylamino)ethyl]-1H-indol-2-yl}[4-(2-chlorophenyl)-1-piperazinyl]methanone structure")
{3-[Bis(4-hydroxyphenyl)methyl]-1-[2-(dimethylamino)ethyl]-1H-indol-2-yl}[4-(2-chlorophenyl)-1-piperazinyl]methanone
CAS Number:
170365-25-0
Molecular Formula:
C36H37ClN4O3
![Heptadecanoic Acid 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl Ester structure](https://static.chemtradehub.com/structs/140/1404053-62-8-9da4.webp "Heptadecanoic Acid 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl Ester structure")
Heptadecanoic Acid 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl Ester
CAS Number:
1404053-62-8
Molecular Formula:
C40H59FN4O4
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.