2-(4-Chlorophenyl)-4-(dimethylamino)-2-(2-(dimethylamino)ethyl)butanenitrile
CAS Number:
1246816-57-8
Molecular Formula:
C16H24ClN3
Fenretinide binding to the lysosomal protein saposin D alters ceramide solubilization and hydrolysis
Literature Information
Publication Date
2020-07-14
DOI
10.1039/D0MD00182A
Impact Factor
0
Authors
Brandon T. Milliken, Lindy Melegari, Gideon L. Smith, Kris Grohn, Fadi Bou-Abdallah
View Original
Abstract
Fenretinide is a synthetic retinoid pharmaceutical linked to ceramide build-up in vivo. Saposin D is an intralysosomal protein necessary for ceramide binding/degradation. We show, via electronic absorption spectroscopy, fluorescence spectroscopy, and ceramide hydrolysis assays, that fenretinide is bound by saposin D {Ka = (1.45 ± 0.49) × 105 M−1}, and affects ceramide solubilization/degradation.
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