Revision in the first steps of the biosynthesis of the red antibiotic prodigiosin: use of a synthetic thioester to validate a new intermediate
Literature Information
Publication Date
2021-01-15
DOI
10.1039/D0CB00173B
Impact Factor
0
Authors
Maxime Couturier, Hiral D. Bhalara, Rita E. Monson, George P. C. Salmond, Finian J. Leeper
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Abstract
A biosynthetic pathway for the red-antibiotic, prodigiosin, was proposed over a decade ago but not all the suggested intermediates could be detected experimentally. Here we show that a thioester that was not originally included in the pathway is an intermediate. In addition, the enzyme PigE was originally described as a transaminase but we present evidence that it also catalyses the reduction of the thioester intermediate to its aldehyde substrate.
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1,2-Diphenyl-4-[2-(phenylsulfinyl)ethyl]-3,5-pyrazolidinedione
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