Practical fluorothiolation and difluorothiolation of alkenes using pyridine-HF and N-thiosuccinimides
Literature Information
Publication Date
2019-11-22
DOI
10.1039/C9QO01228A
Impact Factor
5.281
Authors
Xiaojun Zeng, Bo Xu
View Original
Abstract
We have developed highly efficient fluorothiolation and difluorothiolation of alkenes under simple and mild conditions. Our fluorothiolation reagents are the commercially available Olah's reagent (Py-HF) and readily available N-thiosuccinimides. This transition metal-free system offers good chemical yields for a wide range of alkene substrates with excellent regioselectivity and good functional group tolerance.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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CAS Number:
63039-48-5
Molecular Formula:
C10H15NO4
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