![[1-(5-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]methanol structure](https://static.chemtradehub.com/structs/143/1439822-99-7-6cc9.webp "[1-(5-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]methanol structure")
[1-(5-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]methanol
CAS Number:
1439822-99-7
Molecular Formula:
C10H11N3O
DMF/NaOH/H2O: a metal-free system for efficient and chemoselective reduction of α-ketoamides
Literature Information
Publication Date
2019-09-04
DOI
10.1039/C9QO00842J
Impact Factor
5.281
Authors
Rongcong Ye, Feiyue Hao, Guyue Liu, Qingsong Zuo, Lijun Deng, Zhengneng Jin, Jiashou Wu
View Original
Abstract
We have developed a transition metal free method for efficient and chemoselective reduction of CO bonds using DMF as a hydrogen source and solvent. α-Ketoamides bearing various functional groups are smoothly reduced to α-hydroxyamides in high yields with the present DMF/NaOH/H2O reduction system.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
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