![4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl acetate structure](https://static.chemtradehub.com/structs/740/740081-22-5-f58f.webp "4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl acetate structure")
4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl acetate
CAS Number:
740081-22-5
Molecular Formula:
C17H13ClFN3O3
Littordials A–E, novel formyl-phloroglucinol-β-caryophyllene meroterpenoids from the leaves of Psidium littorale
Literature Information
Publication Date
2019-03-26
DOI
10.1039/C9QO00174C
Impact Factor
5.281
Authors
Jian Xu, Hui-Lin Zhu, Jie Zhang, Wen-Yuan Liu, Jian-Guang Luo, Ke Pan, Wen-Yuan Cao, Qi-Rui Bi
View Original
Abstract
Five novel formyl-phloroglucinol-β-caryophyllene meroterpenoids, namely littordials A–E (1–5), were isolated from the leaves of Psidium littorale. Their structures were established by spectroscopic data and computational methods, and the structure of 1 was confirmed by X-ray crystallography. Littordials A–E feature unusual acyl phloroglucinol units, and 5 possesses a rare 6/7/9/4-fused tetracyclic ring system. Compounds 2, 3 and 5 exhibited cytotoxic activities on two cancer cell lines (MDA-MB-231 and B16) with IC50 values from 6.6 ± 1.5 to 9.2 ± 1.7 μM.
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Source Journal
Organic Chemistry Frontiers
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7.8
Self-citation Rate:
8.7%
Articles per Year:
724
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