Robust synthesis of C-terminal cysteine-containing peptide acids through a peptide hydrazide-based strategy
Literature Information
Publication Date
2019-05-17
DOI
10.1039/C9OB01114E
Impact Factor
3.876
Authors
Bing-Jia Yan, Han-Ying Zhu, Wei-Wei Shi, Tong-Kuai Xi, Jing Shi, Ge-Min Fang
View Original
Abstract
A new robust strategy was reported for the epimerization-free synthesis of C-terminal Cys-containing peptide acids through mercaptoethanol-mediated hydrolysis of peptide thioesters prepared in situ from peptide hydrazides. This simple-to-operate and highly efficient method avoids the use of derivatization reagents for resin modification, thus providing a practical avenue for the preparation of C-terminal Cys-containing peptide acids.
Related Literature
Nanodots of transition metal dichalcogenides embedded in MoS2 and MoSe2: first-principles calculations
Roberto Hiroki Miwa, Wanderlã L. Scopel, Everson S. Souza, José Eduardo Padilha, Adalberto Fazzio
2017-09-21
Paper
DOI: 10.1039/C7CP03761A
Swelling of micro-hydrogels with a crosslinker gradient
Niels Boon, Peter Schurtenberger
2017-06-06
Paper
DOI: 10.1039/C7CP02434G
Concerted double proton-transfer electron-transfer between catechol and superoxide radical anion
Markus Doerr, Martha C. Daza
2017-09-11
Paper
DOI: 10.1039/C7CP03930A
Formation of titanium dioxide core–shell microcapsules through a binary-phase spray technique
Jonatan Bergek, Björn Elgh, Anders E. C. Palmqvist, Lars Nordstierna
2017-07-31
Paper
DOI: 10.1039/C7CP02571H
Enhanced interfacial activity of multi-arm poly(ethylene oxide) star polymers relative to linear poly(ethylene oxide) at fluid interfaces
Yun-Ru Huang, Melissa Lamson, Krzysztof Matyjaszewski
2017-07-10
Paper
DOI: 10.1039/C7CP02841E
Increasing the lifetimes of charge separated states in porphyrin–fullerene polyads
Di Gao, Shawkat M. Aly, Paul-Ludovic Karsenti, Gessie Brisard, Pierre D. Harvey
2017-07-31
Paper
DOI: 10.1039/C7CP04193D
Adsorption of molecular hydrogen on coronene with a new potential energy surface
Massimiliano Bartolomei, Ricardo Pérez de Tudela, Kilian Arteaga, Tomás González-Lezana, Marta I. Hernández, José Campos-Martínez, Pablo Villarreal, Javier Hernández-Rojas, José Bretón
2017-09-05
Paper
DOI: 10.1039/C7CP03819D
A novel combined chemical kinetic and trapping method for probing the relationships between chemical reactivity and interfacial H2O, Br− and H+ ion molarities in CTAB/C12E6 mixed micelles
Laurence S. Romsted, Yongliang Zhang, Xiang Gao, Qing Gu, Changyao Liu
2017-06-12
Paper
DOI: 10.1039/C7CP03413J
A systematic study of the influence of mesoscale structuring on the kinetics of a chemical reaction
Sebastian Krickl, Thomas Buchecker, Andreas Uwe Meyer, Isabelle Grillo, Didier Touraud, Pierre Bauduin, Burkhard König, Arno Pfitzner, Werner Kunz
2017-06-20
Paper
DOI: 10.1039/C7CP02134H
You might also like
Compound Q&A
What is 3-Fluoro-2-methylbenzylamine (CAS: 771573-36-5)?
3-Fluoro-2-methylbenzylamine is an organic compound with the CAS number 771573-3...
771573-36-53-Fluoro-2-methylben...
Compound Q&A
Is Tert-butyl 2-(oxetan-3-ylidene)acetate (CAS: 1207175-03-8) safe?
Tert-butyl 2-(oxetan-3-ylidene)acetate is considered safe for its intended uses ...
1207175-03-8Tert-butyl 2-(oxetan...
Compound Q&A
What precautions should be taken when handling 4-Acetyl-2-fluorobenzonitrile (CAS: 214760-18-6)?
Proper personal protective equipment (PPE) such as gloves, goggles, and a lab co...
214760-18-64-Acetyl-2-fluoroben...
Compound Q&A
How is 2-Ethyl-4-methyl-1,3-thiazole (CAS: 15679-12-6) typically synthesized?
2-Ethyl-4-methyl-1,3-thiazole is commonly synthesized via the reaction of thiour...
15679-12-62-Ethyl-4-methyl-1,3...
Compound Q&A
How should 5',5''-([2,2'-Bithiophene]-5,5'-diyl)bis(([1,1':3',1''-terphenyl]-4,4''-dicarboxylic acid)) (CAS: 1227780-71-3) be stored?
This compound should be stored in a cool, dry place away from direct sunlight an...
1227780-71-35',5''''-([2,2'-Bith...
Compound Q&A
What regulatory guidelines apply to L-Lysine Acetate Salt (CAS: 52315-92-1)?
L-Lysine Acetate Salt (CAS: 52315-92-1) is subject to various regulatory guideli...
52315-92-1L-LYSINE ACETATE SAL...
Compound Q&A
Is 6-Fluoro-3-hydroxy-2-pyrazinecarboxamide (CAS: 259793-96-9) safe?
6-Fluoro-3-hydroxy-2-pyrazinecarboxamide (CAS: 259793-96-9) is generally conside...
259793-96-96-Fluoro-3-hydroxy-2...
Compound Q&A
What are the physical and chemical properties of 1,1'-Sulfonylbis(1H-imidazole) (CAS: 7189-69-7)?
1,1'-Sulfonylbis(1H-imidazole) is a crystalline solid with a molecular weight of...
7189-69-71,1'-Sulfonylbis(1H-...
Compound Q&A
What industries use 4-methyl-7-nitro-1H-indole-3-carbonitrile (CAS: 289483-82-5)?
4-Methyl-7-nitro-1H-indole-3-carbonitrile (CAS: 289483-82-5) is primarily used i...
289483-82-54-methyl-7-nitro-1H-...
Compound Q&A
How should waste containing 5-Bromo-3-indolyl-beta-galactoside (CAS: 97753-82-7) be handled?
Waste containing 5-Bromo-3-indolyl-beta-galactoside (CAS: 97753-82-7) should be ...
97753-82-75-Bromo-3-indolyl-be...
Source Journal
Organic & Biomolecular Chemistry
CiteScore:
3.4
Self-citation Rate:
10.3%
Articles per Year:
1041
Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.
Recommended Compounds
![(3R)-3-(3-Fluorophenyl)-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoic acid structure](https://static.chemtradehub.com/structs/500/500789-04-8-20dd.webp "(3R)-3-(3-Fluorophenyl)-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoic acid structure")
(3R)-3-(3-Fluorophenyl)-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoic acid
CAS Number:
500789-04-8
Molecular Formula:
C14H18FNO4
![5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-2H-pyrazolo[3,4-c]pyridazin-3-amine structure](https://static.chemtradehub.com/structs/865/865362-74-9-0091.webp "5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-2H-pyrazolo[3,4-c]pyridazin-3-amine structure")
5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-2H-pyrazolo[3,4-c]pyridazin-3-amine
CAS Number:
865362-74-9
Molecular Formula:
C18H13N7
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.