Electrochemical trifluoromethylation/semipinacol rearrangement sequences of alkenyl alcohols: synthesis of β-CF3-substituted ketones

Literature Information

Publication Date 2019-03-07
DOI 10.1039/C9OB00373H
Impact Factor 3.876
Authors

Hye Im Jung, Yubin Kim, Dae Young Kim


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Abstract

Electrochemical oxidative radical trifluoromethylation/semipinacol rearrangement sequences of alkenyl alcohols were developed in this study. This approach is environmentally benign and uses the shelf-stable Langlois reagent as a trifluoromethyl radical precursor and electrons as the oxidizing reagents. The present protocol offers a facile route to prepare β-trifluoromethylated ketone derivatives.

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