Discovery of isoxazolyl-based inhibitors of Plasmodium falciparum cGMP-dependent protein kinase
Literature Information
Publication Date
2019-12-16
DOI
10.1039/C9MD00511K
Impact Factor
0
Authors
Shams Ul Mahmood, Huimin Cheng, Sreedhar R. Tummalapalli, Ramappa Chakrasali, Rammohan R. Yadav Bheemanaboina, Tamara Kreiss, Agnieska Chojnowski, Tyler Eck, John J. Siekierka, David P. Rotella
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Abstract
The cGMP-dependent protein kinase in Plasmodium falciparum (PfPKG) plays multiple roles in the life cycle of the parasite. As a result, this enzyme is a potential target for new antimalarial agents. Existing inhbitors, while potent and active in malaria models are not optimal. This communication describes initial optimization of a structurally distinct class of PfPKG inhibitors.
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Source Journal
Recommended Compounds
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CAS Number:
1246816-57-8
Molecular Formula:
C16H24ClN3
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5-Methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-amine
CAS Number:
1227210-33-4
Molecular Formula:
C7H12N4
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