Synthesis and scale-up of water-soluble quaternary cationic monomers in a continuous flow system
Literature Information
Zheng Fang, Yuhang Yang, Jiajia Gu, Zhao Yang, Feiyang Dai, Haoliang Zheng, Wei He, Chengkou Liu, Ning Zhu
A continuous flow technology was developed for the synthesis and scale-up of water-soluble quaternary cationic monomers represented by dimethyldiallylammonium chloride (DMDAAC) in a self-designed reactor. For industrial applications, static mixers were employed in a self-designed scaled-up reactor to maintain the mass and heat transfer rates from microfluidics to mesofluidics during the scale-up. Three different types of static mixers were investigated, and their optimal combination was determined. Various factors including the reaction temperature, fluid rate, and reagent concentration were also investigated in detail. This work increased the yield up to 92% under optimal conditions with an output of one kiloton per year. Moreover, this proposed method exhibited excellent performance in the synthesis and scale-up of other water-soluble quaternary cationic monomers in a continuous flow system.
Recommended Journals
Related Literature
The dissociation kinetics of dissolved metal–humate complexes
Samantha J. King, Peter Warwick, Anthony Hall, Nicholas D. Bryan
DOI: 10.1039/B004899M
A study of the reactions of trifluoromethyl sulfur pentafluoride, SF5CF3, with several positive ions of atmospheric interest
C. Atterbury, R. A. Kennedy, C. A. Mayhew, R. P. Tuckett
DOI: 10.1039/B102504J
Excited state spectroscopy and dynamics of isolated adenine and 9-methyladenine
DOI: 10.1039/B101191J
The effect of chiral end groups on the assembly of supramolecular polyurethanes
Daniel Hermida-Merino, Lewis R. Hart, Peter J. Harris, Andrew T. Slark, Ian W. Hamley, Wayne Hayes
DOI: 10.1039/D1PY00714A
The interaction of oligo(ethylene glycol) with water: Testing an atomistic force field for transferability
Alexander J. Pertsin, Tomohiro Hayashi, Michael Grunze
DOI: 10.1039/B100097G
A reinterpretation of the EPR spectra of Cu(II) in zeolites A, Y and ZK4, based on ab initio cluster model calculations
Kristine Pierloot, Annelies Delabie, Marijke H. Groothaert, Robert A. Schoonheydt
DOI: 10.1039/B100531F
Inhibition of Jahn–Teller cooperative distortion in LiMn2O4 spinel by transition metal ion doping
Doretta Capsoni, Marcella Bini, Gaetano Chiodelli, Vincenzo Massarotti, Carlo B. Azzoni, Maria Cristina Mozzati, Alberto Comin
DOI: 10.1039/B100080M
Homo- and copolymerization of norbornene using tridentate IzQO palladium catalysts with dimethylaminoethyl as a side arm‡
Jie Dong
DOI: 10.1039/D1PY00699A
Multiphoton photoelectron spectroscopy: watching molecules dissociate
Bernhard Urban, Vladimir E. Bondybey
DOI: 10.1039/B102772G
You might also like
What regulatory guidelines apply to 6-Bromo-2-methylimidazo[1,2-a]pyrimidine (CAS: 1111638-05-1)?
6-Bromo-2-methylimidazo[1,2-a]pyrimidine (CAS: 1111638-05-1) falls under various...
Are there alternatives to 1-Pyrrolidineethanol, β-methyl-α-phenyl-, (αS,βR) (CAS: 123620-80-4) in synthesis?
While there are no direct alternatives, similar compounds like 1-Pyrrolidineetha...
Is 4-Methyl-2,6-bis(2-methyl-2-propanyl)phenyl methylcarbamate (CAS: 1918-11-2) safe?
4-Methyl-2,6-bis(2-methyl-2-propanyl)phenyl methylcarbamate (CAS: 1918-11-2) is ...
How should 2-(3-Bromo-4-fluorophenyl)-1,3-dioxolane (CAS: 77771-04-1) be stored?
2-(3-Bromo-4-fluorophenyl)-1,3-dioxolane (CAS: 77771-04-1) should be stored in a...
What are the physical and chemical properties of 4,5,6,7-Tetrahydro-1H-indazole hydrochloride (CAS: 18161-11-0)?
4,5,6,7-Tetrahydro-1H-indazole hydrochloride is a white crystalline solid with a...
What is (2R)-1-Methoxy-3-phenyl-2-propanamine (CAS: 59919-07-2)?
(2R)-1-Methoxy-3-phenyl-2-propanamine is a chiral organic compound with the CAS ...
What industries use Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate (CAS: 56649-47-9)?
Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate is used in various industries...
What regulatory guidelines apply to 4-[(1E,3S)-1-(4-Hydroxyphenyl)-1,4-pentadien-3-yl]phenol (CAS: 17676-24-3)?
4-[(1E,3S)-1-(4-Hydroxyphenyl)-1,4-pentadien-3-yl]phenol (CAS: 17676-24-3) falls...
What industries use (S)-3-Amino-5-phenylpentanoic acid hydrochloride (CAS: 331846-97-0)?
(S)-3-Amino-5-phenylpentanoic acid hydrochloride is primarily used in the pharma...
How is 7-methoxy-1-benzothiophene-2-carboxylic acid (CAS: 88791-07-5) typically synthesized?
7-Methoxy-1-benzothiophene-2-carboxylic acid is typically synthesized by reactin...
Source Journal
Reaction Chemistry & Engineering

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.














![Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, compd. with 1-pyrrolidineethanol (1:1) structure Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, compd. with 1-pyrrolidineethanol (1:1) structure](https://static.chemtradehub.com/structs/119/119623-66-4-5301.webp)