Fischernolides A–D, four novel diterpene-based meroterpenoid scaffolds with antitumor activities from Euphorbia fischeriana
Literature Information
Publication Date
2019-02-15
DOI
10.1039/C8QO01379A
Impact Factor
5.281
Authors
Jun He, Yung-Chi Cheng, Pei-Cheng Zhang, Yu Yan, Hao-Jun Zhang, Wei-Ku Zhang, Jie-Kun Xu
View Original
Abstract
Fischernolides A–D (1–4), four meroterpenoids based on diterpene and acylphloroglucinol, possessing an unprecedented 28-carbon skeleton with a novel scaffold, were isolated from the roots of Euphorbia fischeriana. Their structures and absolute configurations were determined by comprehensive chemical analyses including spectroscopic techniques, electronic circular dichroism (ECD) spectroscopy, and single crystal X-ray diffraction experiments. The possible biogenetic pathway to generate 1–4 through aldol condensation was also proposed. Compound 2 showed significant cytotoxicity and can induce the apoptosis of MCF-7 and Bel-7402 cell lines by caspase activation.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
2-Methyl-2-propanyl 4-iodo-1-piperidinecarboxylate
CAS Number:
301673-14-3
Molecular Formula:
C10H18INO2
![10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine structure](https://static.chemtradehub.com/structs/292/29216-28-2-1d81.webp "10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine structure")
10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine
CAS Number:
29216-28-2
Molecular Formula:
C20H22N2S
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