Palladium-catalyzed denitrogenative cycloadditions and alkenylations of benzotriazoles with alkynes
Literature Information
Publication Date
2018-08-24
DOI
10.1039/C8QO00778K
Impact Factor
5.281
Authors
Yuanhao Wang, Zhiguo Wang, Xuewei Chen
View Original
Abstract
The palladium-catalyzed denitrogenative formal [2 + 2 + 1]- and [2 + 2 + 2]-cycloadditions of benzotriazoles with internal alkynes have been achieved under different reaction conditions, which enable the efficient access of highly substituted 5,6-spiro bicycles and naphthalenes, respectively. In addition, the palladium-catalyzed denitrogenative alkenylations of benzotriazoles with terminal alkynes are also reported, which offers an efficient method to access ortho-amino styrenes. The present work shows that benzotriazoles could serve as capable precursors for the divergent syntheses of various valuable scaffolds.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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Heptadecanoic Acid 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl Ester
CAS Number:
1404053-62-8
Molecular Formula:
C40H59FN4O4
![(3S,4aS,8aS)-2-[(2R,3S)-3-Amino-2-hydroxy-4-phenylbutyl]-N-(2-methyl-2-propanyl)decahydro-3-isoquinolinecarboxamide structure](https://static.chemtradehub.com/structs/136/136522-17-3-4d77.webp "(3S,4aS,8aS)-2-[(2R,3S)-3-Amino-2-hydroxy-4-phenylbutyl]-N-(2-methyl-2-propanyl)decahydro-3-isoquinolinecarboxamide structure")
(3S,4aS,8aS)-2-[(2R,3S)-3-Amino-2-hydroxy-4-phenylbutyl]-N-(2-methyl-2-propanyl)decahydro-3-isoquinolinecarboxamide
CAS Number:
136522-17-3
Molecular Formula:
C24H39N3O2
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