Catalytic enantioselective and regioselective substitution of 2,3-indolyldimethanols with enaminones
Literature Information
Publication Date
2018-08-08
DOI
10.1039/C8QO00565F
Impact Factor
5.281
Authors
Yi-Nan Lu, Chun Ma, Jin-Ping Lan, Caiqiang Zhu, Yu-Jia Mao, Guang-Jian Mei, Shu Zhang, Feng Shi
View Original
Abstract
2,3-Indolyldimethanols as a new class of indolyldimethanols have been designed, and the first catalytic asymmetric substitution of 2,3-indolyldimethanols has been established by using cyclic enaminones as nucleophiles, which afforded substitutive products in an enantioselective and regioselective mode (up to 98% ee, all >95 : 5 rr). This reaction represents the first design and application of 2,3-indolyldimethanols in catalytic asymmetric reactions, which will greatly enrich the chemistry of indolyldimethanols.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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CAS Number:
1404053-62-8
Molecular Formula:
C40H59FN4O4
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