Copper-catalyzed arene amination in pure aqueous ammonia

Literature Information

Publication Date 2018-11-19
DOI 10.1039/C8OB02708K
Impact Factor 3.876
Authors

Mio Takagi, Ayako Watanabe, Shigeo Murata, Ryo Takita


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Abstract

A simple protocol for copper-catalyzed arene amination using aqueous ammonia without any additional ligands and organic coordinating solvents has been developed. The reaction pathway via a Cu(I)/Cu(III) mechanism is proposed based on the results of control experiments as well as DFT calculations.

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Contents list

Front/Back Matter

DOI: 10.1039/C7CP90217D

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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry
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Self-citation Rate: 10.3%
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Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

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