Photoinduced CO release, cellular uptake and cytotoxicity of a tris(pyrazolyl)methane (tpm) manganese tricarbonyl complex
Literature Information
Johanna Niesel, Antonio Pinto, Harmel W. Peindy N'Dongo, Klaus Merz, Ingo Ott, Ronald Gust, Ulrich Schatzschneider
Cell viability studies of HT29 colon cancer cells treated with the CO-releasing compound [Mn(CO)3(tpm)]PF6 revealed a significant photoinduced cytotoxicity comparable to that of established agent 5-fluorouracil (5-FU), while controls kept in the dark were unaffected at up to 100 µM.
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