Exploring the relationship between cocrystal stability and symmetry: is Wallach's rule applicable to multi-component solids?
Literature Information
Tomislav Friščić, László Fábián, Jonathan C. Burley, David G. Reid, Melinda J. Duer, William Jones
Comparison of structure and hydration stability of pairs of chiral and racemic binary cocrystals indicates that the racemic solid is more stable than the chiral one; we illustrate that this difference might arise from intermolecular (crystal packing) factors in one case, while intramolecular (molecular conformation) factors are more significant in the other.
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