Exploring the relationship between cocrystal stability and symmetry: is Wallach's rule applicable to multi-component solids?

Literature Information

Publication Date 2008-01-30
DOI 10.1039/B717532A
Impact Factor 6.222
Authors

Tomislav Friščić, László Fábián, Jonathan C. Burley, David G. Reid, Melinda J. Duer, William Jones


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Abstract

Comparison of structure and hydration stability of pairs of chiral and racemic binary cocrystals indicates that the racemic solid is more stable than the chiral one; we illustrate that this difference might arise from intermolecular (crystal packing) factors in one case, while intramolecular (molecular conformation) factors are more significant in the other.

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