Small molecule–protein interactions in branch migration thermodynamics: modelling and application in the homogeneous detection of proteins and small molecules
Literature Information
Publication Date
2018-05-14
DOI
10.1039/C8AN00555A
Impact Factor
4.616
Authors
Zhangbo Cui, Liquan Liu, Ziyong Sun, Meng Lin, Qingyi Hu, Hongbo Wang, Xianjin Xiao
View Original
Abstract
We have disclosed the unique inhibition effect of small molecule–protein interactions toward the DNA branch migration process and constructed a complete thermodynamic model for it. The disclosed effect was further coupled with the steric hindrance effect to establish a homogeneous assay for proteins and small molecules with ultra-high inhibition factors and sensitivity.
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