The growing role of structural mass spectrometry in the discovery and development of therapeutic antibodies
Literature Information
Publication Date
2018-04-30
DOI
10.1039/C8AN00295A
Impact Factor
4.616
Authors
Yuwei Tian, Brandon T. Ruotolo
View Original
Abstract
The comprehensive structural characterization of therapeutic antibodies is of critical importance for the successful discovery and development of such biopharmaceuticals, yet poses many challenges to modern measurement science. Mass spectrometry has evolved into a rapid and sensitive tool for assessing the structures, stabilities, and dynamics of such proteins. Here, we review the current state-of-the-art mass spectrometry technologies focusing on the characterization of antibody-based therapeutics. We conclude by discussing the future of structural mass spectrometry, and its role in enabling the biopharmaceutical pipeline.
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Analyst
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Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
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Molecular Formula:
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