Hydrolysis resistant functional polypeptide scaffold for biomaterials
Literature Information
Publication Date
2017-12-21
DOI
10.1039/C7PY01586K
Impact Factor
5.582
Authors
View Original
Abstract
For biomaterials, rich functionality often comes at a cost of precise control over structure. In this paper, we have developed a hydrolysis resistant polypeptide that marries the potential for expansive modification with synthetic control. This polymer, poly(γ-propargyl-L-glutamine) may be prepared from commercially available or previously synthesized poly(L-glutamate) by routine amide bond coupling reactions on a multi gram scale. Afterwards, the polymer may be altered to suit many applications through modification of the side chains or end group by orthogonal and quantitative reactions. The ease of synthesis and versatile nature of poly(γ-propargyl-L-glutamine) makes it a unique and ideal scaffold for biomaterial applications.
Related Literature
Functional analysis of the biomimetic silica precipitating activity of the R5 peptide from Cylindrotheca fusiformis
Marc R. Knecht, David W. Wright
2003-11-03
Communication
DOI: 10.1039/B309074D
Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase
Carlos Olano, Barrie Wilkinson, Steven J. Moss, Alfredo F. Braña, Carmen Méndez, José A. Salas
2003-10-15
Communication
DOI: 10.1039/B310648A
Potassium–zinc induced synergic enhancement of the basicity of hexamethyldisilazide (HMDS) towards methylbenzene molecules
William Clegg, Glenn C. Forbes, Alan R. Kennedy, Robert E. Mulvey, Stephen T. Liddle
2003-01-14
Communication
DOI: 10.1039/B211392A
Small molecule fixation by a dithiadiazolyl radical: X-ray crystal structures of (CF3C6H3FCNSSN)2 and (CF3C6H3FCNSSN)2˙G (G = N2, Ar, CO2 and SO2)
Caroline S. Clarke, Delia A. Haynes, Jeremy M. Rawson, Andrew D. Bond
2003-10-20
Communication
DOI: 10.1039/B307509P
Two-dimensional metamagnet composed of cyano-bridged CuII–WV bimetallic assembly
Yoichi Arimoto, Toshiya Hozumi, Hidetake Seino, Yasushi Mizobe, Kazuhito Hashimoto
2003-10-20
Communication
DOI: 10.1039/B310456G
Molecular recognition. Electrostatic effects in supramolecular self-assembly
James D. Crowley, Andrew J. Goshe, B. Bosnich
2003-01-14
Communication
DOI: 10.1039/B210957C
Photo-induced colour generation and colour erasing switched by the sol–gel phase transition
Tao Yi, Kazuki Sada, Kazunori Sugiyasu, Tsukasa Hatano, Seiji Shinkai
2003-01-14
Communication
DOI: 10.1039/B210741D
A novel approach to polymeric hollow nanospheres with stabilized structure
Min Kuang, Hongwei Duan, Jing Wang, Daoyong Chen, Ming Jiang
2003-01-22
Communication
DOI: 10.1039/B210851H
Photoinduced Ba2+ release and thermal rebinding by an azacrown ether linked by an alkynyl pyridine to a (bpy)Re(CO)3 group
Jared D. Lewis, John N. Moore
2003-10-22
Communication
DOI: 10.1039/B309436G
Synthesis and characterization of luminescent osmium(ii) carbonyl complexes based on chelating dibenzoylmethanate and halide ligands
Yao-Lun Chen, Chittaranjan Sinha, I-Chia Chen, Kuan-Lin Liu, Yun Chi, Jen-Kan Yu, Pi-Tai Chou, Tian-Huey Lu
2003-10-31
Communication
DOI: 10.1039/B308340C
You might also like
Compound Q&A
What precautions should be taken when handling lithium chloride hydrate (1:1:1) (CAS: 16712-20-2)?
When handling lithium chloride hydrate (1:1:1) (CAS: 16712-20-2), it is importan...
16712-20-2Lithium chloride hyd...
Compound Q&A
Is 4-(4H-1,2,4-Triazol-4-yl)piperidine (CAS: 690261-92-8) safe?
4-(4H-1,2,4-Triazol-4-yl)piperidine is generally considered safe for use in phar...
690261-92-84-(4H-1,2,4-Triazol-...
Compound Q&A
How should waste containing 1,3-Thiazole-2-carboxamide (CAS: 16733-85-0) be handled?
Waste containing 1,3-Thiazole-2-carboxamide (CAS: 16733-85-0) should be collecte...
16733-85-01,3-Thiazole-2-carbo...
Compound Q&A
What regulatory guidelines apply to 5-(Difluoromethyl)-2-fluorobenzonitrile (CAS: 934175-58-3)?
5-(Difluoromethyl)-2-fluorobenzonitrile (CAS: 934175-58-3) is subject to regulat...
934175-58-35-(Difluoromethyl)-2...
Compound Q&A
How is Methyl 3-acetamido-2-thiophenecarboxylate (CAS: 22288-79-5) typically synthesized?
Methyl 3-acetamido-2-thiophenecarboxylate can be synthesized by the reaction of ...
22288-79-5Methyl 3-acetamido-2...
Compound Q&A
What is 4-Isoquinolinecarbonitrile (CAS: 34846-65-6)?
4-Isoquinolinecarbonitrile is a chemical compound with the CAS number 34846-65-6...
34846-65-64-Isoquinolinecarbon...
Compound Q&A
How should Methyl 1H-1,2,3-triazole-4-carboxylate (CAS: 877309-59-6) be stored?
Store Methyl 1H-1,2,3-triazole-4-carboxylate (CAS: 877309-59-6) in a cool, dry p...
877309-59-6Methyl 1H-1,2,3-tria...
Compound Q&A
What regulatory guidelines apply to 6-Bromo[1,3]thiazolo[5,4-b]pyridin-2-amine (CAS: 1160791-13-8)?
6-Bromo[1,3]thiazolo[5,4-b]pyridin-2-amine (CAS: 1160791-13-8) is subject to the...
1160791-13-86-Bromo[1,3]thiazolo...
Compound Q&A
Is (2S,3S)-2-Ammonio-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoate (CAS: 23651-95-8) safe?
(2S,3S)-2-Ammonio-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoate (CAS: 23651-95-8) ...
23651-95-8(2S,3S)-2-Ammonio-3-...
Compound Q&A
What are the physical and chemical properties of 7-bromo-3-methyl-3,4-dihydroquinazolin-4-one (CAS: 1293987-84-4)?
7-Bromo-3-methyl-3,4-dihydroquinazolin-4-one is a solid with a crystalline form....
1293987-84-47-bromo-3-methyl-3,4...
Source Journal
Polymer Chemistry
CiteScore:
8.6
Self-citation Rate:
7.3%
Articles per Year:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
Recommended Compounds
![Ethyl 4-[8-chloro(5,5,6,6,7-~2~H_5_)-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidinecarboxylate structure](https://static.chemtradehub.com/structs/102/1020719-57-6-37e2.webp "Ethyl 4-[8-chloro(5,5,6,6,7-~2~H_5_)-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidinecarboxylate structure")
Ethyl 4-[8-chloro(5,5,6,6,7-~2~H_5_)-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidinecarboxylate
CAS Number:
1020719-57-6
Molecular Formula:
C22H18D5ClN2O2
![N-[2-(2-Pyridinyl)ethyl]-1-propanamine structure](https://static.chemtradehub.com/structs/554/55496-57-6-22b4.webp "N-[2-(2-Pyridinyl)ethyl]-1-propanamine structure")
![6-(Benzyloxy)-8-(2-bromoacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one structure](https://static.chemtradehub.com/structs/926/926319-53-1-2287.webp "6-(Benzyloxy)-8-(2-bromoacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one structure")
6-(Benzyloxy)-8-(2-bromoacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
CAS Number:
926319-53-1
Molecular Formula:
C17H14BrNO4
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.