![7-Bromo-5-chloro-1H-pyrazolo[4,3-b]pyridine structure](https://static.chemtradehub.com/structs/135/1351813-70-1-a716.webp "7-Bromo-5-chloro-1H-pyrazolo[4,3-b]pyridine structure")
Tailoring the properties of a hypoxia-responsive 1,8-naphthalimide for imaging applications
Literature Information
Publication Date
2018-01-05
DOI
10.1039/C7OB03164E
Impact Factor
3.876
Authors
Kylie Yang, Kathryn G. Leslie, Sally Y. Kim, Bill Kalionis
View Original
Abstract
Sensing hypoxia in tissues and cell models can provide insights into its role in disease states and cell development. Fluorescence imaging is a minimally-invasive method of visualising hypoxia in many biological systems. Here we present a series of improved bioreductive fluorescent sensors based on a nitro-naphthalimide structure, in which selectivity, photophysical properties, toxicity and cellular uptake are tuned through structural modifications. This new range of compounds provides improved probes for imaging and monitoring hypoxia, customised for a range of different applications. Studies in monolayers show the different reducing capabilities of hypoxia-resistant and non-resistant cell lines, and studies in tumour models show successful staining of the hypoxic region.
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Source Journal
Organic & Biomolecular Chemistry
CiteScore:
3.4
Self-citation Rate:
10.3%
Articles per Year:
1041
Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.
Recommended Compounds
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N-[4-(Cyanoethynyl)phenyl]-16-oxo-4,7,10,13-tetraoxa-17-azahenicos-1-yn-21-amide
CAS Number:
2183440-36-8
Molecular Formula:
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Bis(N,N''-dimethylpiperazine)tetra[copper(I) iodide]
CAS Number:
1401708-91-5
Molecular Formula:
C12H28Cu4I4N4
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