An intramolecular tryptophan-condensation approach for peptide stapling
Literature Information
Eunice Y.-L. Hui, Bhimsen Rout, Yaw Sing Tan, Kok-Ping Chan, Charles W. Johannes
Stapled peptides are gaining tremendous interest as next-generation therapeutic agents to target protein–protein interactions. Herein, we report an intramolecular peptide stapling method which links two tryptophan residues at the C2 position of the indole moieties via acid-mediated condensation with an aldehyde.
Recommended Journals
Related Literature
Magnetic properties of a doped linear polyarylamine bearing a high concentration of coupled spins (S = 1)
Vincent Maurel, Mohammad Jouni, Piotr Baran, Nicolas Onofrio, Serge Gambarelli, Jean-Marie Mouesca, David Djurado, Lionel Dubois, Jean-François Jacquot, Gérard Desfonds, Irena Kulszewicz-Bajer
DOI: 10.1039/C1CP22766A
Steering the enzymatic activity of proteins by ionic liquids. A case study of the enzyme kinetics of yeast alcohol dehydrogenase
Sebastian Weibels, Adrian Syguda, Christian Herrmann, Hermann Weingärtner
DOI: 10.1039/C2CP24041F
Structure, reactivity, photoactivity and stability of Ti–O based materials: a theoretical comparison
Yun Wang, Tao Sun, Dongjiang Yang, Hongwei Liu, Haimin Zhang, Xiangdong Yao, Huijun Zhao
DOI: 10.1039/C2CP23143C
A first-principles study of ultrathin nanofilms of MgO-supported TiN
Ren-Qin Zhang, Chang-Eun Kim, Bernard Delley, Catherine Stampfl, Aloysius Soon
DOI: 10.1039/C2CP23534J
Time-resolved vibrational spectroscopy of a molecular shuttle
Matthijs R. Panman, Pavol Bodis, Danny J. Shaw, Bert H. Bakker, Arthur C. Newton, Euan R. Kay, David A. Leigh, Wybren Jan Buma, Albert M. Brouwer, Sander Woutersen
DOI: 10.1039/C1CP22146A
Intermolecular acetaldehyde and dimethoxymethane formation mechanisms viaethenol and methoxymethylene precursors in reactions of atomic carbon with methanol: a computational study
Yavuz Dede, Ilker Ozkan
DOI: 10.1039/C2CP23127A
Operando DRIFTS study of the redox and catalytic properties of CuO/Ce1−xTbxO2−δ (x = 0–0.5) catalysts: evidence of an induction step during CO oxidation
A. Martínez-Arias, A. B. Hungría, M. Fernández-García, A. Iglesias-Juez, J. Soria, J. C. Conesa, J. A. Anderson, G. Munuera
DOI: 10.1039/C1CP23298C
Covalent bond orders and atomic anisotropies from iterated stockholder atoms
Richard J. Wheatley, Angelica A. Gopal
DOI: 10.1039/C2CP23504H
Formation and oxidation mechanisms of Pd–Zn nanoparticles on a ZnO supported Pd catalyst studied by in situ time-resolved QXAFS and DXAFS
Yasuhiro Inada, Yasuhiro Niwa, Masao Kimura, Kyoko K. Bando, Akira Yagishita, Yasuhiro Iwasawa, Masaharu Nomura
DOI: 10.1039/C1CP22466B
You might also like
What are the main uses of (3.beta.)-3-Hydroxy-N,N-dimethyl-chol-5-en-24-amide (CAS: 79066-03-8)?
(3.beta.)-3-Hydroxy-N,N-dimethyl-chol-5-en-24-amide (CAS: 79066-03-8) is primari...
What regulatory guidelines apply to 5-(aminomethyl)-2-methoxyphenol (CAS: 89702-89-6)?
5-(Aminomethyl)-2-methoxyphenol (CAS: 89702-89-6) is classified under GHS as a s...
What is Thieno[2,3-c]pyridin-7(6H)-one (CAS: 28981-13-7)?
Thieno[2,3-c]pyridin-7(6H)-one (CAS: 28981-13-7) is a heterocyclic organic compo...
Is 1-[(6-Methoxy-3-pyridinyl)methyl]-4-piperidinamine dihydrochloride (CAS: 1185311-28-7) safe?
1-[(6-Methoxy-3-pyridinyl)methyl]-4-piperidinamine dihydrochloride is generally ...
What regulatory guidelines apply to [(2E)-3-Phenyl-2-propen-1-yl]phosphonic acid (CAS: 146404-58-2)?
[(2E)-3-Phenyl-2-propen-1-yl]phosphonic acid (CAS: 146404-58-2) is regulated und...
What regulatory guidelines apply to 6-Bromo-7-methoxyquinoline (CAS: 1620515-86-7)?
6-Bromo-7-methoxyquinoline (CAS: 1620515-86-7) falls under the scope of the Glob...
What industries use (2R)-1-(1-Benzofuran-2-yl)-N-propyl-2-pentanamine (CAS: 260550-89-8)?
This compound is primarily used in the pharmaceutical industry for the developme...
What are the main uses of 1-Ethyl-7-[2-methyl-6-(4H-1,2,4-triazol-3-yl)-3-pyridinyl]-3,5-dihydropyrazino[2,3-b]pyrazin-2(1H)-one (CAS: 1228013-15-7)?
1-Ethyl-7-[2-methyl-6-(4H-1,2,4-triazol-3-yl)-3-pyridinyl]-3,5-dihydropyrazino[2...
Are there alternatives to {5-(Acryloylamino)-2-[(dimethylamino)methyl]phenyl}boronic acid (CAS: 1217500-78-1) in synthesis?
Alternative reagents such as 2-[(dimethylamino)methyl]phenylboronic acid or rela...
What is 3-(Piperidin-4-yloxy)pyridine (CAS: 310881-48-2)?
3-(Piperidin-4-yloxy)pyridine (CAS: 310881-48-2) is an organic compound with the...
Source Journal
Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.














amine structure [(2-chlorophenyl)methyl](ethyl)amine structure](https://static.chemtradehub.com/structs/629/62924-61-2-0728.webp)