An intramolecular tryptophan-condensation approach for peptide stapling
Literature Information
Publication Date
2017-12-08
DOI
10.1039/C7OB02667F
Impact Factor
3.876
Authors
Eunice Y.-L. Hui, Bhimsen Rout, Yaw Sing Tan, Kok-Ping Chan, Charles W. Johannes
View Original
Abstract
Stapled peptides are gaining tremendous interest as next-generation therapeutic agents to target protein–protein interactions. Herein, we report an intramolecular peptide stapling method which links two tryptophan residues at the C2 position of the indole moieties via acid-mediated condensation with an aldehyde.
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Source Journal
Organic & Biomolecular Chemistry
CiteScore:
3.4
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10.3%
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Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.
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amine structure](https://static.chemtradehub.com/structs/629/62924-61-2-0728.webp "[(2-chlorophenyl)methyl](ethyl)amine structure")
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