Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging

Literature Information

Publication Date 2017-03-13
DOI 10.1039/C7AN00076F
Impact Factor 4.616
Authors

C. Taglang, C. von Morze, J. E. Blecha, J. W. Gordon, R. Sriram, D. B. Vigneron, H. F. VanBrocklin, D. M. Wilson, R. R. Flavell


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Abstract

Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-13C,D10]diethylmalonic acid, which exhibits a large pH-dependent 13C chemical shift over the physiological range. We demonstrate that co-polarization with [1-13C,D9]tert-butanol accurately measures pH via13C NMR and magnetic resonance spectroscopic imaging in phantoms.

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