Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging
Literature Information
Publication Date
2017-03-13
DOI
10.1039/C7AN00076F
Impact Factor
4.616
Authors
C. Taglang, C. von Morze, J. E. Blecha, J. W. Gordon, R. Sriram, D. B. Vigneron, H. F. VanBrocklin, D. M. Wilson, R. R. Flavell
View Original
Abstract
Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-13C,D10]diethylmalonic acid, which exhibits a large pH-dependent 13C chemical shift over the physiological range. We demonstrate that co-polarization with [1-13C,D9]tert-butanol accurately measures pH via13C NMR and magnetic resonance spectroscopic imaging in phantoms.
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Recommended Compounds
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725746-35-0
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1,10-bis(3,5-dimethylphenyl)-12-hydroxy-4,5,6,7-tetrahydroiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocine 12-oxide
CAS Number:
1412439-82-7
Molecular Formula:
C33H31O4P
![1-[6-(1H-Imidazol-1-yl)-3-pyridinyl]methanamine structure](https://static.chemtradehub.com/structs/914/914637-08-4-8825.webp "1-[6-(1H-Imidazol-1-yl)-3-pyridinyl]methanamine structure")
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