Efficient synthesis of multiply substituted butenolides from keto acids and terminal alkynes promoted by combined acids
Literature Information
Wenbin Mao
A general, efficient, and operationally simple approach to highly substituted butenolides through the annulation of keto acids and terminal alkynes is described. This reaction is promoted by the combination of Lewis and Brønsted acids, furnishing a variety of butenolides in synthetically useful yields.
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Organic Chemistry Frontiers

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry










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