The first biosynthetic studies of the azinomycins: acetate incorporation into azinomycin B

Literature Information

Publication Date 2004-03-19
DOI 10.1039/B400093E
Impact Factor 6.222
Authors

Christophe Corre, Philip A. S. Lowden


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Abstract

13 C-Labelled acetate efficiently labels the antitumour natural product azinomycin B, revealing a polyketide origin for the naphthoate fragment, that threonine is the probable precursor of the enol fragment, and that α-ketoglutarate is a probable precursor of the aziridine fragment.

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