Elucidation of the mechanism of chiral selectivity in diastereomeric salt formation using organic solventnanofiltration

Literature Information

Publication Date 2004-03-11
DOI 10.1039/B400982G
Impact Factor 6.222
Authors

Nazlee F. Ghazali, Darrell A. Patterson, Andrew G. Livingston


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Abstract

Organic solvent nanofiltration (OSN) was used to investigate the mechanism of chiral selectivity in diastereomeric salt formation of α-phenylethylamine with D-tartaric acid and di-p-toluoyl-D-tartaric acid as resolving agents; results indicate that for these systems chiral selectivity occurs only upon crystallisation and chiral interactions in solution were negligible.

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