Synthesis of 2,3-dihydrobenzofurans via the palladium catalyzed carboalkoxylation of 2-allylphenols
Literature Information
Publication Date
2016-08-22
DOI
10.1039/C6QO00215C
Impact Factor
5.281
Authors
Johnathon T. Hutt, John P. Wolfe
View Original
Abstract
A new Pd-catalyzed alkene carboalkoxylation strategy for the preparation of 2,3-dihydrobenzofurans is described. This method effects the coupling of readily available 2-allylphenol derivatives with aryl triflates to generate a wide range of functionalized 2,3-dihydrobenzofurans in good yields and diastereoselectivities (up to >20 : 1). Use of newly developed reaction conditions that promote anti-heteropalladation of the alkene is essential in order to generate products in high yield.
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Organic Chemistry Frontiers
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